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Reduction in Lethal Effect of X-Radiation by Pretreatment with Thiourea or Sodium Ethane Dithiophosphonate

Nature volume 166, page 515 (1950)Cite this article

Abstract

DALE et al.1 showed that carboxypolypeptidase could be protected in vitro against X-radiation by a variety of substances. One of these, thiourea, is shown below to reduce the mortality following whole-body irradiation of mice. We also tried a few other substances, selected, like thiourea, in the hope that they would enter cells without being too toxic or too rapidly metabolized, and would protect by competing for hydroxyl radicals. The effect of sodium ethane-dithiophosphonate is of added interest because sodium ethane-monothiophosphonate protects weakly against the radiomimetic substance bis-chlorethyl sulphide (mustard gas)2.

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References

  1. Dale, W. M., Davies, J. V., and Meredith, W. J., Brit. J. Cancer, 3, 31 (1949).

    Article  CAS  Google Scholar 

  2. Holiday, E. R., Philpot, J. St. L., and Stocken, E. L. (in preparation).

  3. Fisher, R. A., “Statistical Methods for Research Workers”, p. 96 (10th edit., Oliver and Boyd).

  4. Patt, H. M., Tyree, E. B., Straube, R. L., and Smith, D. E., Science, 110, 213 (1949).

    Article  ADS  CAS  Google Scholar 

  5. Chapman, W. H., Sipe, C. R., Eltzholtz, L. C., Cronkite, E. P., and Chambers, F. W., jun., Naval Medical Research Institute, National Naval Medical Centre, Bethesda, Ma., Project NM 006 012.08.25.

  6. Bacq, Z. M., Herve, A., Lecomte, J., and Fischer, P., Science, 111, 356 (1950).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Medical Research Council Radiobiological Research Unit, Atomic Energy Research Establishment, Harwell, Didcot, Berks

    R. H. MOLE, J. ST. L. PHILPOT & G. R. V. HODGES

Authors
  1. R. H. MOLE
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  2. J. ST. L. PHILPOT
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  3. G. R. V. HODGES
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MOLE, R., PHILPOT, J. & HODGES, G. Reduction in Lethal Effect of X-Radiation by Pretreatment with Thiourea or Sodium Ethane Dithiophosphonate. Nature 166, 515 (1950). https://doi.org/10.1038/166515a0

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