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Nucleic Acid Content of Tumour Cells

Nature volume 166, pages 832–833 (1950)Cite this article

Abstract

IT has been suggested1,2 that the quantity of deoxypentosenucleic acid is constant for different somatic cells in the same species. On this assumption, the deoxypentosenucleic acid content of different tumour cells can be compared with that of normal cells from the same species. Many efforts have been made to compare the deoxypentosenucleic acid content of homologous normal and neoplastic tissues (see reviews in refs. 3 and 4). The results are rather divergent, several authors having reported an increase in deoxypentosenucleic acid in tumour cells, whereas others failed to observe any difference. We have found the Ehrlich ascites tumour of mice to be a good material for determinations of the average nucleic acid content of a single tumour cell5,6 and have found the deoxypentosenucleic acid content of such cells to be about twice as great as that of normal mouse cells6,7.

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References

  1. Vendrely, R., and Vendrely, C., Experientia, 5, 327 (1949).

    Article  CAS  Google Scholar 

  2. Mirsky, A. E., and Ris, H., Nature, 163, 666 (1949).

    Article  ADS  CAS  Google Scholar 

  3. Schneider, W. C., Cold Spring Harbor Symp. Quant. Biol., 12, 169 (1947).

    Article  CAS  Google Scholar 

  4. Stowell, R. E., Symp. Soc. Exp. Biol., 1, 190 (1947).

    Google Scholar 

  5. Klein, E., Kurnick, N. B., and Klein, G., Exp. cell Res., 1, 127 (1950).

    Article  CAS  Google Scholar 

  6. Goldberg, L., Klein, E., and Klein, G., Exp. Cell Res. (in the press).

  7. Klein, G., Cancer (in the press).

  8. Krebs, C., Thordarson, O., and Harbo, J., Acta Radiol., Supp. 44 (1942).

  9. Caspersson, T., and Santesson, L., Acta Radiol., Supp. 46 (1942).

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Authors and Affiliations

  1. Department of Cell Research, Karolinska Institute, Stockholm

    E. KLEIN & G. KLEIN

Authors
  1. E. KLEIN
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  2. G. KLEIN
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KLEIN, E., KLEIN, G. Nucleic Acid Content of Tumour Cells. Nature 166, 832–833 (1950). https://doi.org/10.1038/166832a0

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