Abstract
THE biosynthesis of kojic acid by Aspergillus oryzæ has been investigated by growing the mould on Czapek–Dox medium containing l-C14-glucose1 and 0.1 per cent yeast extract. Surface cultures were grown in 1-litre conical flasks through which air was continuously passed. The radioactive carbon was located by degrading dimethylkojic acid as shown below2 (the carbon atoms of kojic acid have been numbered from 1 to 6 in order to simplify subsequent comparison with glucose).
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ARNSTEIN, H., BENTLEY, R. Kojic Acid Biosynthesis from 1-C14-Glucose. Nature 166, 948–949 (1950). https://doi.org/10.1038/166948a0
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DOI: https://doi.org/10.1038/166948a0
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