Abstract
IT has been shown in a series of recent papers1"3 that baker's yeast grown in the presence of acriflavine undergoes a profound modification. After a few generations of growth in the presence of the dye, the culture is found to be composed almost exclusively of cells which are deficient in some respiratory enzymes (cytoehrome oxidase, succinic dehydro-genase) and which are consequently unable to oxidize glucose. Cells presenting these characteristics have been isolated in pure cultures which have been maintained in normal rnedium for several years. Their respiratory deficiency has proved to be permanent.
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References
Ephrussi, B., Hottinguer, H., and Chiménes, A. M., Ann. Inst. Pasteur, 76, 351 (1949).
Slonimski, P. P., Ann. Inst. Pasteur, 76, 510 (1949).
Slonimski, P. P., and Ephrusst, B., Ann. Inst. Pasteur, 77, 47 (1949).
Ephrussi, B., L'Héritier, Ph., and Hottinguer, H., Ann. Inst. Pasteur, 77, 64 (1949).
This compound, kindly given to U9 by Prof. Adrien Albert, has been found to be particularly active (Marcovich, H., unpublished).
Ephrussi, B., Hottinguer, H., and Tavlitzki, J., Ann. Inst. Pasteur, 76, 419 (1949).
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EPHRUSSI, B., HOTTINGUER, H. Direct Demonstration of the Mutagenic Action of Euflavine on Baker's Yeast. Nature 166, 956 (1950). https://doi.org/10.1038/166956a0
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DOI: https://doi.org/10.1038/166956a0
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