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Effect of Diet on Toxicity to Rabbits of the Toxic Factor from ‘Agenized’ Flour

Abstract

THE toxic factor present in ‘agenized’ flour was isolated1 and later synthesized2 by Moran and his colleagues at St. Albans. These workers had found that oral doses of about 5 mgm. of the dl-compound or 2 mgm. of the l-compound caused convulsions in more than 90 per cent of the rabbits dosed (they used animals of about 600–800 gm.). Our first attempts to confirm the convulsive effect were completely negative: doses up to 20 mgm. of the dl-compound or 10 mgm. of the l-compound had no effect whatever in our animals.

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References

  1. Bentley, H. R., McDermott, E. E., Pace, J., Whitehead, J. K., and Moran, T., Nature, 164, 438 (1949); 165, 150 (1950).

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  2. Bentley, H. R., McDermott, E. E., and Whitehead, J. K., Nature, 165, 753 (1950).

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  3. Heathcote, J. G., and Pace, J., Nature, 166, 353 (1950).

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BROOM, W., GURD, M. & HARMER, G. Effect of Diet on Toxicity to Rabbits of the Toxic Factor from ‘Agenized’ Flour. Nature 167, 772–773 (1951). https://doi.org/10.1038/167772b0

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