Abstract
M. Fabinyi and J. Szebehelyi1 have reported that histamine neutralizes the inhibition of hyaluronidase with heparin. We had already dealt with the problem of the influence of histamine on the system hyaluronic acid – hyaluronidase – hyaluronidase-inhibiting agents. Since we had not observed any effect of histamine at that time, we decided to repeat our investigations. Unfortunately, the communication by Fabinyi and Szebehelyi gives no information as to the source of their hyaluronic acid and hyaluronidase, or the concentrations used in their investigations; and we have received no reply to a request for further information.
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References
Fabinyi, M., and Szebehelyi, J., Nature, 163, 533 (1949).
Swyer, G. I. M., Biochem. J., 42, 28 (1948).
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SEELICH, F., HÜBL, P. Effect of Histamine on the Activity of Hyaluronidase. Nature 168, 1125 (1951). https://doi.org/10.1038/1681125a0
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DOI: https://doi.org/10.1038/1681125a0
