Abstract
IT has been known for some time that di-iso-fluorophosphonate and similar drugs, which are anti-cholinesterases in nature, in toxic doses produce syndromes resembling certain psychoses, and that in schizophrenics they aggravate signs and symptoms1. Conversely, it was thought that cholinesterase and other drugs counteracting acetylcholine should reduce the manifestations of schizophrenia, and they have done so, on injection into the cerebral ventricles of man2.
Similar content being viewed by others
Article PDF
References
Rowntree, D. W., Nevin, S., and Wilson, A., J. Neurol., Neurosurg. Psychiat., 13, 47 (1950).
Sherwood, S. L., Brain (in the press).
Dempsey, E. W., and Morison, R. S., Amer. J. Physiol., 135, 293 (1942).
Starzl, T. E., and Magoun, H. W., J. Neurophysiol., 14, 133 (1951).
Cannon, W. L., and Rosenblueth, A., “Supersensitivity of Denervated Structures” (Macmillan, New York, 1949).
Dale, Sir Henry, Bull. Acad. Med., 13, 379 (1937).
Lettvin, J. Y. (personal communication, 1951).
Ingram, W. R., and Ranson, S. W., Arch. Neurol. Psychiat., 31 987 (1934).
Bailey, P., J. Nerv. Ment. Dis., 107, 336 (1948).
Michel, Harry O., J. Lab. Clin. Med., 34, 1564 (1949).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SHERWOOD, S., RIDLEY, E. & McCULLOCH, W. Effects of Intraventricular Acetylcholine, Cholinesterase, and Related Compounds in Normal and ‘Catatonic’ Cats. Nature 169, 157 (1952). https://doi.org/10.1038/169157a0
Issue date:
DOI: https://doi.org/10.1038/169157a0
This article is cited by
-
Differentiation between nervous and humoral influences by simultaneous recording of the motor activity of innervated and denervated loops of small intestine
Bulletin of Experimental Biology and Medicine (1964)
