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Effects of Intraventricular Acetylcholine, Cholinesterase, and Related Compounds in Normal and ‘Catatonic’ Cats

Nature volume 169, page 157 (1952)Cite this article

Abstract

IT has been known for some time that di-iso-fluorophosphonate and similar drugs, which are anti-cholinesterases in nature, in toxic doses produce syndromes resembling certain psychoses, and that in schizophrenics they aggravate signs and symptoms1. Conversely, it was thought that cholinesterase and other drugs counteracting acetylcholine should reduce the manifestations of schizophrenia, and they have done so, on injection into the cerebral ventricles of man2.

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Author notes

  1. STEPHEN L. SHERWOOD: On a research grant from the Middlesex Hospital, London.

Authors and Affiliations

  1. Department of Psychiatry, University of Illinois College of Medicine, Chicago, Illinois

    STEPHEN L. SHERWOOD, ELLEN RIDLEY & WARREN S. McCULLOCH

Authors
  1. STEPHEN L. SHERWOOD
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  2. ELLEN RIDLEY
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  3. WARREN S. McCULLOCH
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SHERWOOD, S., RIDLEY, E. & McCULLOCH, W. Effects of Intraventricular Acetylcholine, Cholinesterase, and Related Compounds in Normal and ‘Catatonic’ Cats. Nature 169, 157 (1952). https://doi.org/10.1038/169157a0

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