Feasibility of Quantitative Separation of the Threo- and Erythro-Forms of Amino-Acids by Column Chromatography

Abstract

THE methods that are at present available for the separation of the diastereoisomeric forms of amino-acids are subject to several limitations. In the usual fractionation procedures only one of the isomers, at most, is obtained pure, the other remaining contaminated. A high degree of purity is realized only at the expense of yield. The difficulties inherent in isotopic synthesis make the above operations increasingly wasteful, thus further limiting the practicability of these methods.