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Double high-dose chemotherapy with autologous peripheral stem cell rescue in relapsed Wilms’ tumor

Bone Marrow Transplantation volume 20, pages 1111–1113 (1997)Cite this article

Abstract

We performed double high-dose chemotherapy (HDCT) and autologous stem cell rescue (ASCR) on an 8-year-old girl after relapse of Wilms’ tumor with unfavorable histology. Relapse occurred while the patient was still on first-line therapy and showed multiple adverse prognostic features. Since depleted hematopoietic reserves restricted further conventional therapy, a double HDCT approach was chosen to achieve maximal dose intensity. Four years after relapse the girl is in second remission and well. Double HDCT with ASCR may represent a feasible approach to rescue extensively pretreated patients with recurrent Wilms’ tumor of unfavorable histology.

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Authors and Affiliations

  1. Department of Pediatrics, University Hospital, Innsbruck, Austria

    K Maurer, A Heitger & FM Fink

  2. Division of Clinical Immunobiology and Bone Marrow Transplantation, Department of Internal Medicine, University Hospital, Innsbruck, Austria

    H Schwaighofer & D Niederwieser

Authors
  1. K Maurer
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  2. A Heitger
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  3. H Schwaighofer
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  4. FM Fink
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  5. D Niederwieser
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Maurer, K., Heitger, A., Schwaighofer, H. et al. Double high-dose chemotherapy with autologous peripheral stem cell rescue in relapsed Wilms’ tumor. Bone Marrow Transplant 20, 1111–1113 (1997). https://doi.org/10.1038/sj.bmt.1701030

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  • DOI: https://doi.org/10.1038/sj.bmt.1701030

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