Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Immunologic recovery of patients given CD34-selected peripheral blood progenitor cell transplantation for malignant diseases

Bone Marrow Transplantation volume 25, pages 223–224 (2000)Cite this article

Access through your institution
Buy or subscribe

In summary, transplantation of CD34-selected PBPC allows rapid and sustained hematologic engraftment. No marked delay of immune reconstitution compared with unseparated PBPC recipients was observed in our study.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. Attal M, Harousseau JL, Stoppa AM et al. A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma New Engl J Med 1996 335: 91–97

    Article  CAS  Google Scholar 

  2. Philip T, Chauvin F, Armitage J et al. Parma international protocol: pilot study of DHAP followed by involved-field radiotherapy and BEAC with autologous bone marrow transplantation Bone Marrow Transplant 1991 77: 1587–1592.

    CAS  Google Scholar 

  3. Shpall EJ, Jones RB, Bearman SI et al. Transplantation of enriched CD34-positive autologous marrow into breast cancer patients following high-dose chemotherapy: influence of CD34-positive peripheral-blood progenitors and growth factors on engraftment J Clin Oncol 1994 12: 28–36

    Article  CAS  Google Scholar 

  4. Brugger W, Henschler R, Shelly H et al. Positively selected autologous blood CD34+ cells and unseparated peripheral blood progenitor cells mediate identical hematopoietic engraftment after high-dose VP16, ifosfamide, carboplatin, and epirubicin Blood 1994 84: 1421–1426

    CAS  PubMed  Google Scholar 

  5. Lowdell MW, Craston R, Ray N et al. The effect of T cell depletion with Campath 1M on immune reconstitution after chemotherapy and allogeneic bone marrow transplantation as treatment for leukemia Bone Marrow Transplant 1998 21: 679–686

    Article  CAS  Google Scholar 

  6. Anderson K, Soiffer R, DeLage R et al. T-cell depleted autologous bone marrow transplantation therapy: analysis of immune deficiency and late complications Blood 1990 76: 235–244

    CAS  PubMed  Google Scholar 

  7. Bomberger C, Singh-Jairam M, Rodey G et al. Lymphoid reconstitution after autologous PBSC transplantation with FACS-sorted CD34+ hematopoietic progenitors Blood 1998 91: 2588–2600

    CAS  PubMed  Google Scholar 

  8. Dreger P, Viehmann K, von Neuhoff N et al. Autografting of highly purified peripheral blood progenitor cells following myeloablative therapy in patients with lymphoma: a prospective study of the long-term effects on tumor eradication, reconstitution of hematopoiesis and immune recovery BoneMarrow Transplant 1999 24: 153–161

    CAS  Google Scholar 

  9. Guillaume T, Rubinstein DB, Symann M . Immune reconstitution and immunotherapy after autologous hematopoietic stem cell transplantation Blood 1998 92: 1471–1490

    CAS  PubMed  Google Scholar 

  10. Talmadge JE, Reed E, Ino K et al. Rapid immunologic reconstitution following transplantation with mobilized peripheral blood stem cells as compared to bone marrow Bone Marrow Transplant 1997 19: 161–172

    Article  CAS  Google Scholar 

  11. Bilgrami S, Chakraborty NG, Rodriguez-Pinero F et al. Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue Bone Marrow Transplant 1999 23: 469–474

    Article  CAS  Google Scholar 

  12. Brugger SA, Kalhs P, Keil F et al. Haematological and immunological reconstitution after high dose radio and/or chemotherapy with supportive infusion of unselected and CD34+-enriched peripheral stem cells Ann Hematol 1996 73: (Suppl. 2) 657

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Mediicine I, Bone Marrow Transplantation Unit, University of Vienna, Vienna, A-1090, Austria

    A Schulenburg, P Kalhs & HT Greinix

  2. Department of Transfusion Medicine, University of Vienna, Vienna, A-1090, Austria

    N Worel & P Höcker

  3. Department of Medicine I, Division of Hematology and Homostaseology, Waehringer Guertel 18-20, University of Vienna, Vienna, A-1090, Austria

    P Knöbl

Authors
  1. A Schulenburg
    View author publications

    Search author on:PubMed Google Scholar

  2. P Kalhs
    View author publications

    Search author on:PubMed Google Scholar

  3. N Worel
    View author publications

    Search author on:PubMed Google Scholar

  4. P Höcker
    View author publications

    Search author on:PubMed Google Scholar

  5. P Knöbl
    View author publications

    Search author on:PubMed Google Scholar

  6. HT Greinix
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schulenburg, A., Kalhs, P., Worel, N. et al. Immunologic recovery of patients given CD34-selected peripheral blood progenitor cell transplantation for malignant diseases. Bone Marrow Transplant 25, 223–224 (2000). https://doi.org/10.1038/sj.bmt.1702124

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/sj.bmt.1702124

This article is cited by

Search

Advanced search

Quick links