Abstract
FK506-related leukoencephalopathy has been reported to be reversible and readily treated by discontinuation or reduction of FK506. We describe two pediatric cases of FK506-related leukoencephalopathy following allogeneic bone marrow transplantation, which could not be readily controlled. These cases show that FK506-related leukoencephalopathy is not always reversible, and patients may develop epilepsy. Bone Marrow Transplantation (2000) 25, 331–334.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout



Similar content being viewed by others
References
Freise CE, Rowley H, Lake J et al. Similar clinical presentation of neurotoxicity following FK506 and cyclosporine in a liver transplant recipient Transplant Proc 1991 23: 3173–3174
Small SL, Fukui MB, Bramblett GT, Eidelman BH . Immunosuppression-induced leukoencephalopathy from tacrolimus (FK506) Ann Neurol 1996 40: 575–580
Thyagarajan GK, Cobanoglu A, Johnston W . FK506-induced fulminant leukoencephalopathy after single-lung transplantation Ann Thorac Surg 1997 64: 1461–1464
Shutter LA, Green JP, Newman NJ et al. Cortical blindness and white matter lesions in a patient receiving FK506 after liver transplantation Neurology 1993 43: 2417–2418
Pizzolato GP, Sztajzel R, Burkhardt K et al. Cerebral vasculitis during FK506 treatment in liver transplant patient Neurology 1998 50: 1154–1157
Hinchey J, Chaves C, Appignani B et al. A reversible posterior leukoencephalopathy syndrome New Engl J Med 1996 334: 494–500
Steg RE, Kessinger A, Wszolek ZK . Cortical blindness and seizures in a patient receiving FK506 after bone marrow transplantation Bone Marrow Transplant 1999 23: 959–962
Pettitt AR, Clark RE . Thrombotic microangiopathy following bone marrow transplantation Bone Marrow Transplant 1994 14: 495–504
Iwasaki Y, Sako K, Ohara Y et al. Subacute panencephalitis associated with chronic graft-versus-host disease Acta Neuropathol 1993 85: 566–572
Sharkey J, Butcher SP . Immunophilins mediate the neuroprotective effect of FK506 in focal cerebral ischaemia Nature 1994 371: 336–339
Steiner JP, Dawson TM, Fotuhi M et al. High brain densities of the immunophilin FKBP colocalized with calcineurin Nature 1992 358: 584–587
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Misawa, A., Takeuchi, Y., Hibi, S. et al. FK506-induced intractable leukoencephalopathy following allogeneic bone marrow transplantation. Bone Marrow Transplant 25, 331–334 (2000). https://doi.org/10.1038/sj.bmt.1702143
Received:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1038/sj.bmt.1702143
Keywords
This article is cited by
-
Posterior reversible encephalopathy syndrome (PRES) after haploidentical haematopoietic stem cell transplantation: incidence, risk factors and outcomes
Bone Marrow Transplantation (2020)
-
Progressive neurological disease induced by tacrolimus in a renal transplant recipient: Case presentation
BMC Nephrology (2006)


