Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Potential allogeneic graft-versus-tumor effect in a patient with ovarian cancer

Abstract

A 33-year-old woman developed progressive ovarian cancer resistant to classical chemotherapy agents. We performed a bone marrow allograft after a myeloablative regimen. During hematological recovery, she developed acute graft-versus-host disease (GVHD). From this time her tumor diminished progressively. One year post transplant she has limited chronic liver GVHD and is still free of disease. The complete remission of advanced ovarian cancer was probably related to the GVHD which might therefore provide a new treatment option for this disease. Bone Marrow Transplantation (2000) 25, 681–682.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Ben-Yosef R, Nagler A, Slavin S . Graft-versus-tumor and graft-versus-leukaemia effect in patient with concurrent breast cancer and acute myelocytic leukaemia Lancet 1996 348: 1242–1243

    Article  CAS  Google Scholar 

  2. Ueno NT, Rondon G, Mirza NQ et al. Allogeneic peripheral-blood progenitor-cell transplantation for poor-risk patients with metastatic breast cancer J Clin Oncol 1998 16: 986–993

    Article  CAS  Google Scholar 

  3. Childs RW, Clave E, Tisdale J et al. Successful treatment of metastatic renal cell carcinoma with a nonmyeloablative allogeneic peripheral-blood progenitor-cell transplant: evidence for a graft-versus-tumor effect J Clin Oncol 1999 17: 2044–2049

    Article  CAS  Google Scholar 

  4. Kaye SB, Eisenhauer EA, Hamilton TC . New non-cytotoxic approaches to ovarian cancer Ann Oncol 1999 10: 65–68

    Article  Google Scholar 

  5. Legros M, Dauplat J, Fleury J et al. High-dose chemotherapy with hematopoietic rescue in patients with stage III to IV ovarian cancer: long-term results J Clin Oncol 1997 15: 1302–1308

    Article  CAS  Google Scholar 

  6. Slavin S, Nagler A, Naparstek E et al. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases Blood 1998 3: 756–763

    Google Scholar 

Download references

Author information

Authors and Affiliations

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bay, J., Choufi, B., Pomel, C. et al. Potential allogeneic graft-versus-tumor effect in a patient with ovarian cancer. Bone Marrow Transplant 25, 681–682 (2000). https://doi.org/10.1038/sj.bmt.1702206

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/sj.bmt.1702206

Keywords

This article is cited by

Search

Quick links