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Early allogeneic blood stem cell transplantation after modified conditioning therapy during marrow aplasia: stable remission in high-risk acute myeloid leukemia

Abstract

Two patients with high-risk acute myeloid leukemia (AML) whose bone marrow aspirates showed more than 25% blasts between 2 and 4 weeks after the first induction chemotherapy immediately received modified conditioning therapy with intravenous busulfan at 50% of the usual dose and fludarabine, before hematologic recovery occurred. Unmanipulated G-CSF mobilized peripheral blood stem cells from an HLA-identical sibling donor were transfused and haematopoietic recovery was achieved in both recipients. Both of them are in continuing hematological remission with full donor chimerism 12 and 22 months after transplantation. Early treatment intensification with allogeneic cell therapy during marrow aplasia might cure high-risk AML patients who are unlikely to achieve remission with conventional chemotherapy protocols. Bone Marrow Transplantation (2001) 27, 543–546.

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References

  1. Keating MJ, Smith TL, Gehan EA et al. Factors related to length of complete remission in adult acute leukemia Cancer 1980 45: 2017–2029

    Article  CAS  Google Scholar 

  2. Berman E, Little C, Gee T et al. Reasons that patients with acute myelogenous leukemia do not undergo allogeneic bone marrow transplantation New Engl J Med 1992 326: 156–160

    Article  CAS  Google Scholar 

  3. Estey E, Shen Y, Thall PF . Effect of time to complete remission on subsequent survival and disease-free survival time in AML, RAEB-t, and RAEB Blood 2000 95: 72–77

    CAS  PubMed  Google Scholar 

  4. Grigg AP, Szer J, Beresford J et al. Factors affecting the outcome of allogeneic bone marrow transplantation for adult patients with refractory or relapsed acute leukemia Br J Haematol 1999 107: 409–418

    Article  CAS  Google Scholar 

  5. Thiede C, Florek M, Bornhäuser M et al. Rapid quantification of mixed chimerism using multiplex amplification of short tandem repeat markers and fluorescence detection Bone Marrow Transplant 1999 23: 1055–1060

    Article  CAS  Google Scholar 

  6. Clift RA, Buckner CD, Appelbaum FR et al. Allogeneic marrow transplantation during untreated first relapse of acute myeloid leukemia J Clin Oncol 1992 10: 1723–1729

    Article  CAS  Google Scholar 

  7. Byrne JL, Dasgupta E, Pallis M et al. Early allogeneic transplantation for refractory or relapsed acute leukaemia following remission induction with FLAG Leukemia 1999 13: 786–791

    Article  CAS  Google Scholar 

  8. Slavin S, Nagler A, Naparstek E et al. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases Blood 1998 91: 756–763

    CAS  Google Scholar 

  9. McSweeney PA, Wagner JL, Maloney DG et al. Outpatient PBSC allografts using immunosuppression with low-dose TBI before, and cyclosporine (CSP) and mycophenolate mofetil (MMF) after transplant Blood 1998 92: (Suppl. 1) 519a

    Google Scholar 

  10. Xun CQ, McSweeney PA, Boeckh M et al. Successful nonmyeloablative allogeneic hematopoietic stem cell transplant in an acute leukemia patient with chemotherapy-induced marrow aplasia and progressive pulmonary aspergillosis Blood 1999 94: 3273–3276

    CAS  PubMed  Google Scholar 

  11. Bornhäuser M, Thiede C, Schuler U et al. Dose-reduced conditioning for allogeneic blood stem cell transplantation: durable engraftment without antithymocyte globulin Bone Marrow Transplant 2000 26: 119–125

    Article  Google Scholar 

  12. Harousseau JL, Cahn JY, Pignon B et al. Comparison of autologous bone marrow transplantation and intensive chemotherapy as postremission therapy in adult acute myeloid leukemia. The Groupe Ouest Est Leucemies Aigues Myeloblastiques (GOELAM) Blood 1997 90: 2978–2986

    CAS  PubMed  Google Scholar 

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Platzbecker, U., Thiede, C., Freiberg-Richter, J. et al. Early allogeneic blood stem cell transplantation after modified conditioning therapy during marrow aplasia: stable remission in high-risk acute myeloid leukemia. Bone Marrow Transplant 27, 543–546 (2001). https://doi.org/10.1038/sj.bmt.1702819

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