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Amiodarone and cyclophosphamide: potential for enhanced lung toxicity

Bone Marrow Transplantation volume 27, pages 1109–1111 (2001)Cite this article

Abstract

Antineoplastic therapy can be associated with drug-induced lung toxicity. With the increasing use of amiodarone for cardiac dysrhythmias there is an increasing possibility of its combined use with chemotherapies for various malignancies. We report a patient on long-term amiodarone who developed biopsy-proven drug-induced lung toxicity after receiving high-dose cyclophosphamide, at a time-frame much shorter than would have been predicted with cyclophosphamide alone. The potential for enhanced lung toxicity secondary to combination of amiodarone and cyclophosphamide is discussed. Bone Marrow Transplantation (2001) 27, 1109–1111.

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Acknowledgements

This work was funded in part by National Institutes of Health, National Research Service Award HL07538 to RB and a National Institutes of Health Grant HL55166 to RJF.

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Authors and Affiliations

  1. Division of Pulmonary and Critical Care Medicine, Duke University Adult Bone Marrow Transplant Program, Duke University Medical Center, Durham, NC, USA

    R Bhagat & RJ Folz

  2. Division of Pulmonary and Critical Care Medicine, Department of Pathology, Duke University Adult Bone Marrow Transplant Program, Duke University Medical Center, Durham, NC, USA

    TA Sporn

  3. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Duke University Adult Bone Marrow Transplant Program, Duke University Medical Center, Durham, NC, USA

    GD Long

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  1. R Bhagat
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  2. TA Sporn
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Bhagat, R., Sporn, T., Long, G. et al. Amiodarone and cyclophosphamide: potential for enhanced lung toxicity. Bone Marrow Transplant 27, 1109–1111 (2001). https://doi.org/10.1038/sj.bmt.1703039

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