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Progressive interstitial fibrosis of the lung in sclerodermoid chronic graft-versus-host disease

Bone Marrow Transplantation volume 29, pages 357–360 (2002)Cite this article

Abstract

Sclerodermoid chronic graft-versus-host disease (sGVHD) is a well-known complication in patients with a long history of chronic GVHD. Pulmonary involvement in chronic GVHD presents typically as bronchiolitis obliterans (BO). Pulmonary fibrosis after allogeneic hematopoietic stem cell transplantation (HSCT) is presumed to be caused by the long-term toxicity of the conditioning regimen or the result of lung injury elicited predominantly by viral infections or GVHD. We present two patients with late onset pulmonary fibrosis associated with moderate sGVHD of the skin after HSCT. At the initial diagnosis of chronic GVHD both patients presented with symptoms of interstitial pneumonia. Years later both patients developed moderate to severe interstitial pulmonary fibrosis in association with sGVHD. One patient showed additional clinical and histological signs of BO. While one patient responded to increased immunosuppression including total nodal irradiation (1 Gy), the other patient died due to complications related to pulmonary fibrosis.

Bone Marrow Transplantation (2002) 29, 357–360. doi:10.1038/sj.bmt.1703386

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Authors and Affiliations

  1. Division of Hematology and Oncology, Department of Internal Medicine, University of Rostock, Germany

    D Wolff, B Steiner, C Kahl, M Leithäuser & M Freund

  2. Division of Pneumology, Department of Internal Medicine, University of Leipzig, Germany

    F Reichenberger

  3. Division of Hematology and Oncology, Department of Internal Medicine, University of Leipzig, Germany

    T Skibbe & W Helbig

  4. Department of Pathology, University of Leipzig, Germany

    T Friedrich

  5. Department of Pathology, University of Rostock, Germany

    H Terpe

Authors
  1. D Wolff
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  2. F Reichenberger
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  3. B Steiner
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  4. C Kahl
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  5. M Leithäuser
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Wolff, D., Reichenberger, F., Steiner, B. et al. Progressive interstitial fibrosis of the lung in sclerodermoid chronic graft-versus-host disease. Bone Marrow Transplant 29, 357–360 (2002). https://doi.org/10.1038/sj.bmt.1703386

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