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Hemophagocytic syndrome: a rare complication of allogeneic nonmyeloablative hematopoietic stem cell transplantation

Bone Marrow Transplantation volume 29, pages 799–801 (2002)Cite this article

Abstract

We report two cases of patients with malignant lymphoma who presented with early onset of hemophagocytic syndrome after nonmyeloablative allogeneic peripheral blood stem cell transplantation. Fever and skin eruption developed early after transplantation, and neurological symptoms preceded cytopenia and worsened progressively. Activated macrophages with hemophagocytosis were found in bone marrow of the two patients at day 15 and 56, respectively. The fact that no obvious infectious agents associated with hemophagocytic syndrome were detected, and that serum soluble interleukin-2 receptor concentrations were elevated in the early phase after transplantation, reflecting the activation of donor-derived T cells, suggests that this complication resulted from an alloimmune response.

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Authors and Affiliations

  1. Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Y Abe, I Choi, K Hara, T Matsushima, H Nawata & K Muta

  2. Blood Transfusion Service, Kyushu University Hospital, Fukuoka, Japan

    S Inaba

  3. Department of Clinical Immunology, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan

    J Nishimura

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  1. Y Abe
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  2. I Choi
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  3. K Hara
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  6. S Inaba
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  7. H Nawata
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  8. K Muta
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Abe, Y., Choi, I., Hara, K. et al. Hemophagocytic syndrome: a rare complication of allogeneic nonmyeloablative hematopoietic stem cell transplantation. Bone Marrow Transplant 29, 799–801 (2002). https://doi.org/10.1038/sj.bmt.1703554

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  • DOI: https://doi.org/10.1038/sj.bmt.1703554

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