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Post-Transplant Complications

Successful treatment of post-transplant lymphoproliferative disorder in autologous blood stem cell transplant recipients

Bone Marrow Transplantation volume 30, pages 321–326 (2002)Cite this article

Abstract

We report three cases of post-transplant lymphoproliferative disorder (PTLD) in the context of autologous stem cell transplantation (ASCT) for multiple myeloma (MM) and non-Hodgkin's lymphoma. The first two cases received ASCT for MM, one with a CD34-selected autograft and the other with an unmanipulated autograft. Both these cases of PTLD achieved a complete response following treatment with IVIG, gancyclovir, solumedrol and interferon (IFN). The third case received ASCT with an unmanipulated autograft for relapsed angioimmunoblastic lymphoma. He also achieved a complete response but only after rituximab was added to IVIG, gancyclovir, solumedrol and IFN. None of these patients experienced a relapse of their PTLD with follow-up ranging from 1.5 to 5 years. These cases highlight the importance of considering PTLD in the differential diagnosis of lymphadenopathy and fever post ASCT. They also demonstrate the possibility of durable complete remission of post-ASCT PTLD following antiviral and immune modulating therapy.

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Authors and Affiliations

  1. Department of Medicine, University of Calgary and Tom Baker Cancer Center, Calgary, Alberta, Canada

    D Jenkins, A Chaudhry, D Morris, S Glück, A Jones, R Woodman, CB Brown, J Russell & DA Stewart

  2. Department of Pathology, University of Calgary and Tom Baker Cancer Center, Calgary, Alberta, Canada

    L DiFrancesco

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  1. D Jenkins
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  2. L DiFrancesco
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  3. A Chaudhry
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  4. D Morris
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Jenkins, D., DiFrancesco, L., Chaudhry, A. et al. Successful treatment of post-transplant lymphoproliferative disorder in autologous blood stem cell transplant recipients. Bone Marrow Transplant 30, 321–326 (2002). https://doi.org/10.1038/sj.bmt.1703603

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