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Psychological Issues

Neuropsychological outcome in long-term survivors of a childhood extracranial solid tumor who have undergone autologous bone marrow transplantation

Bone Marrow Transplantation volume 31, pages 599–606 (2003)Cite this article

Summary:

The purpose of this study was to evaluate neuropsychological and adaptive functioning of children who have undergone bone marrow transplantation (BMT) without previous cranial irradiation. In total, 76 children treated for an extracranial tumor with BMT without total body irradiation (TBI) were evaluated at least 5 years after the end of the treatment.Overall, their performance and skills were in the normal range and their professional and academic outcomes were satisfactory. Nevertheless, we observed a deleterious effect of deafness on verbal IQ associated with the previous administration of cisplatin during conventional chemotherapy. In addition, reading difficulties had arisen. This could be related to absence from kindergarten or primary school during hospitalization. Finally, in the younger subgroup, visual–perceptual skills were found to be more fragile.

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References

  1. Arvidson J, Kihlgen M, Hall C et al. Neuropsychological functioning after treatment for hematological malignancies in childhood, including autologous bone marrow transplantation. Pediatr Hematol-Oncol 1999; 16: 9–21.

    Article  CAS  PubMed  Google Scholar 

  2. Cool VA . Long-term neuropsychological risks in pediatric bone marrow transplant: what do we know. Bone Marrow Transplant 1996; 18S: 45–S49.

    Google Scholar 

  3. Smedler AC, Ringden K, Bergman H et al. Sensory-motor and cognitive functioning in children who have undergone bone marrow transplantation. Acta Paediatr Scand 1990; 79: 613–621.

    Article  CAS  PubMed  Google Scholar 

  4. Smedler AC, Bolme P . Neuropsychological deficits in very young bone marrow transplant recipients. Acta Paediatr 1995; 84: 429–433.

    Article  CAS  PubMed  Google Scholar 

  5. Brown RT, Madan-Swain A, Pais R . Chemotherapy for acute lymphoblastic leukemia: cognitive and academic sequelae. J Pediatr 1992; 121: 885–889.

    Article  CAS  PubMed  Google Scholar 

  6. Ochs J, Mulhern R, Fairclough D et al. Comparison of neuropsychologic functioning and clinical neurotoxicity in long-term survivors of childhood leukemia given cranial radiation or parenteral methotrexate: a prospective study. J Clin Oncol 1991; 9: 145–151.

    Article  CAS  PubMed  Google Scholar 

  7. Copeland DR, Dowell RE, Fletcher JM et al. Neuropsychological effects of childhood cancer treatment. J Child Neurol 1988; 3: 53–62.

    Article  CAS  PubMed  Google Scholar 

  8. Troy L, McFarland K, Littman-Power S et al. Cisplatin-based therapy: a neurological and neuropsychological review. Psycho-Oncology 2000; 9: 29–39.

    Article  CAS  PubMed  Google Scholar 

  9. Copeland DR, Moor III BD, Franci DJ et al. Neuropsychological effect of chemotherapy on children with cancer: a longitudinal study. J Clin Oncol 1996; 14: 2826–2835.

    Article  CAS  PubMed  Google Scholar 

  10. Prassopoulos P, Cavouras D, Evlogias N et al. Brain atrophy in children undergoing systemic chemotherapy for extracranial solid tumor. Med Pediatric Oncol 1997; 28: 228–233.

    Article  CAS  Google Scholar 

  11. Moor III BD, Copeland DR, Ried H et al. Neurophysiological basis of cognitive deficits in long-term survivors of childhood cancer. Arch Neurol 1992; 49: 809–817.

    Article  Google Scholar 

  12. Macdonald DR . Neurologic complication of chemotherapy. Neurologic Clin 1991; 9: 955–967.

    Article  CAS  Google Scholar 

  13. Kaleita RA, Sheilds WD, Tesler A et al. Normal neurodevelopment in four young children treated for acute leukemia or aplastic anemia. Pediatrics 1989; 83: 753–757.

    CAS  PubMed  Google Scholar 

  14. Butler RW, Hill JM, Steinherz PG et al. Neuropsychologic effect of cranial irradiation, intrathecal methotrexate, and systemic methotrexate in childhood cancer. J Clin Oncol 1994; 12: 2621–2629.

    Article  CAS  PubMed  Google Scholar 

  15. Muelhern RK, Ochs J, Fairclough D . Deterioration of intellect among children surviving leukemia: IQ test changes modify estimates of treatment toxicity. J Consult Clin Psychol 1992; 60: 477–480.

    Article  Google Scholar 

  16. Phipps S, Brenner M, Heslop H et al. Psychological effects of bone marrow transplantation on children and adolescents: preliminary report of a longitudinal study. Bone Marrow Transplant 1995, 15: 829–835

    CAS  PubMed  Google Scholar 

  17. Phipps S, Dunavant M, Srivastava DR et al. Cognitive and academic functioning in survivors of pediatric bone marrow transplantation. J Clin Oncol 2000; 18: 1004–1011.

    Article  CAS  PubMed  Google Scholar 

  18. Simms S, Kazak AE, Gannon T et al. Neuropsychological outcome of children undergoing bone marrow transplantation. Bone Marrow Transplant 1998; 22: 181–184.

    Article  CAS  PubMed  Google Scholar 

  19. Wechsler D . Manual for the Wechsler Preschool and Primary Scale of Intelligence – Revised. The Psychological Corporation: San Antonio, 1989 (version française, par ECPA: Paris, 1995).

    Google Scholar 

  20. Wechsler D . Manual for the Wechsler Intelligence Scale for Children, 3rd edn. The Psychological Corporation: San Antonio, 1991 (version française, par ECPA: Paris, 1996).

    Google Scholar 

  21. Wechsler D . 2000 Manual for the Wechsler Adult Intelligence Scale, 3rd edn. The Psychological Corporation: San Antonio, 1999 (version française, par ECPA: Paris, 2000).

    Google Scholar 

  22. Rey A . L'examen clinique en psychologie. Presse Universitaire de France: Paris, 1964.

    Google Scholar 

  23. Rey A . Test de copie d'une figure complexe. Editions du Centre de Psychologie Appliquée: Paris, 1959.

    Google Scholar 

  24. Ghent L . Perception of overlapping and embedded figures by children of different ages. Am J Psychol 1956; 69: 575–587.

    Article  CAS  PubMed  Google Scholar 

  25. Lefavrais P . Test de l'alouette. Editions du Centre de Psychologie Appliquée: Paris, 1967.

    Google Scholar 

  26. Girolani-Boulimier A . Les niveaux actuels de la pratique du langage oral et écrit. Masson: Paris, 1984.

    Google Scholar 

  27. Brock PR, Bellman SC, Yeomans EC et al. Cisplatin toxicity in children: a practical grading system. Med Pediatr Oncol 1991; 19: 295–300.

    Article  CAS  PubMed  Google Scholar 

  28. SAS Institute Inc., SAS Language; Reference, Version 6, 1st edn, Cary, NC: SAS Institute Inc., 1990.

  29. Miller L, Link MP, Bologna S et al. Cerebellar atrophy caused by high dose cytosine-arabinoside. CT and MR findings. Am J Radiol 1989; 152: 343–344.

    CAS  Google Scholar 

  30. Tamaroff M, Salwen R, Miller DR et al. Neuropsychologic sequelae in irradiated (1800 rads (r) & 2400 r) and non-irradiated children with acute lymphoblastic leukemia (ALL). Proc Am Soc Clin Oncol 1985; 4: 165 (abstract C-644).

    Google Scholar 

  31. Ivnik RJ, Colligan RC, Obetz SW et al. Neuropsychologic performance among children in remission from acute lymphoblastic leukemia. J Dev Behav Pediatr 1981; 2:29–34.

    Article  CAS  PubMed  Google Scholar 

  32. Jannoun L . Are cognitive and educational development affected by age at which prophylactic therapy is given in acute lymphoblastic leukemia. Arch Dis Child 1983; 58: 953–958.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Tamaroff M, Miller DR, Murphy ML et al. Immediate and long-term post therapy neuropsychologic performance in children with acute lymphoblastic leukemia treated without central nervous system radiation. J Pediatr 1982; 101: 524–529.

    Article  CAS  PubMed  Google Scholar 

  34. Kramer JH, Crittenden MR, DeSantes K et al. Cognitive and adaptative behavior 1 and 3 years following bone marrow transplantation. Bone Marrow Transplant 1997; 19: 607–613.

    Article  CAS  PubMed  Google Scholar 

  35. Chiron C, Jambaque I, Nabbout R et al. The right hemisphere is dominant in human infants. Brain 1997; 120: 1057–1065.

    Article  PubMed  Google Scholar 

  36. Maurer D, Barrera M . Infants' perception of natural and distorted arrangements of a schematic face. Child Dev 1981; 47: 523–527.

    Article  Google Scholar 

  37. Bates E, Thal D, Janowsky J . Early language development and its neural correlates. In: Rapin I, Segalowitz S (eds). Handbook of Neuropsychology. Elsevier: The Netherlands, 1992, pp 69–110.

    Google Scholar 

  38. Whitt JK, Wells RJ, Laurie MM et al. Cranial radiation in childhood acute lymphocytic leukemia: neuropsychologic sequelae. Am J Child 1984; 138: 730–736.

    Article  CAS  Google Scholar 

  39. Tautman PD, Erickson C, Shaffer D et al. Prediction of intellectual deficits in children with acute lymphoblastic leukemia. Dev Behav Pediatr 1988; 9: 122–128.

    Google Scholar 

  40. Association française pour la lecture. Trois ans dans la vie d'un apprentissage. Lire Ecrire au cycle 1. France Quercy: Cahors, 1993.

  41. Mulhern RK, Fairclough D, Ochs J . A prospective comparison of neuropsychologic performance of children surviving leukemia who received 18-Gy, or no cranial irradiation. J Clin Oncol 1991; 9: 1348–1356.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We thank Lorna Saint Ange for her assistance with the preparation of the manuscript, Marie-Claude Mathieu for her help in the study's organization and the children and their families for their participation in the study.

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Authors and Affiliations

  1. Pediatrics Department, Institut Gustave Roussy, Villejuif, France

    P Notteghem, C Soler, V Kieffer-Renaux, D Valteau-Couanet, G Raimondo & O Hartmann

  2. Epidemiology and Biostatistics, Unité Inserm U472, Villejuif, France

    G Dellatolas

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  1. P Notteghem
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  2. C Soler
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  3. G Dellatolas
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Notteghem, P., Soler, C., Dellatolas, G. et al. Neuropsychological outcome in long-term survivors of a childhood extracranial solid tumor who have undergone autologous bone marrow transplantation. Bone Marrow Transplant 31, 599–606 (2003). https://doi.org/10.1038/sj.bmt.1703882

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