Abstract
CREATININE is commonly determined in biological fluids by various modifications of the Jaffe reaction. The method is recognized as being non-specific and must be applied with caution unless there is a large excess of creatinine present over interfering substances. The specificity of the method has been greatly improved by Miller and Dubos1.
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References
Miller, B. F., and Dubos, R., J. Biol. Chem., 121, 457 (1937).
Peters, J. H., J. Biol. Chem., 146, 179 (1942).
Greenwald, I., J. Amer. Chem. Soc., 47, 1443 (1925).
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GARNER, R. Determination of Creatinine. Nature 170, 460–461 (1952). https://doi.org/10.1038/170460b0
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DOI: https://doi.org/10.1038/170460b0
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Determination of Creatinine by the Jaffé Reaction
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