Table 4 Total Bu exposure and outcome

From: Intravenous busulfan in children prior to stem cell transplantation: study of pharmacokinetics in association with early clinical outcome and toxicity

Event

Busulfan AUC (μg/l·h) of total course (mean±s.d. (n))

 

Yes

No

P-value

VOD

60 759±15 193 (n=8)

59 941±15 375 (n=23)

0.90

Alive at day 100

59 684±14 383 (n=24)

61 755±18 436 (n=7)

0.76

Engraftment

60 521±15 128 (n=28)

56 706±17 345 (n=3)

0.68

Leukemic relapse

48 304±2399 (n=2)

60 969±15 253 (n=29)

0.26

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