Figure 2
From: Genomic screening and complications of hematopoietic stem cell transplantation: has the time come?
The hepatic urea cycle. Urea cycle enzymes are localized to either the mitochondrial or cytoplasmic spaces. Dysfunction of either CPSI or OTC results in a fall in citrulline, a rise in ornithine levels, and potentially reduced NO production. CPSI=carbamyl-phosphate synthetase 1; OTC=ornithine transcarbamylase; ASS=arginosuccinate synthetase; ASL=arginosuccinate lyase; ARG=arginase; NOS=nitric oxide synthetase (modified with permission from Summar et al).21
