Table 1 The CPSI T1405N polymorphism and regimen-related organ toxicity in an HSCT cohort (N=195)

From: Genomic screening and complications of hematopoietic stem cell transplantation: has the time come?

CPSI SNP genotype

HVOD N=38 n(%)

ALI mortality N=27 Deaths/no. with ALI (%)

Day 60 mortality N=33 n(%)

AA (n=19)

0 (0)a

0/4 (0)b

1 (3)c

AC (n=91)

22 (58)

11/15 (73)

14 (42)

CC (n=85)

16 (42)

16/21 (76)

18 (55)

  1. HVOD=hepatic veno-occlusive disease; ALI=acute lung injury; SNP=single-nucleotide polymorphism (T1405N).
  2. aFisher's exact P-value=0.028 for comparison with other genotypes.
  3. bFisher's exact P-value=0.008 for comparison of ALI mortality between AA and other genotypes.
  4. cP-value not significant. Differences in risk of HVOD and ALI mortality remained significant (P<0.05) in multivariable analysis.24,32,33
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