Table 3 Candidate gene classes in oxidant toxicities after HSCT (eg lung, liver)

From: Genomic screening and complications of hematopoietic stem cell transplantation: has the time come?

Functional gene class

Examples of genes

Reference(s)

Cellular antioxidant synthesis, metabolism

GCLC, GST

34, 39, 40, 79

Cytokines, chemokines, and their receptors

IL-10, TNF-α, MCP-1 CCR-1, IL-6, IFN-γ

15, 16, 41, 42 43, 48, 77, 121, 122

Vascular tone, integrity, remodeling

ACE, MTHFR, serotonin transportera

44, 49 50 51 52 53 54, 74

Growth factors

TGF-β

123

Proteases/antiproteases

MMPa, BMPR (type II)a

2, 29

Genes involved in iron transport and metabolism

HFE

32, 33, 96, 124

Nitrogen/NO metabolism

CPSI

5, 21

Cytochrome P-450 metabolism

CYP3A, CYP2E a

15, 125, 126

Coagulation factors

Factor V Leiden, Prothrombin

15, 38, 41, 46, 47

Mitochondrial haplotypes

None

127

  1. Genes: GCLC, glutamate L-cysteine ligase; ACE, angiotensin-converting enzyme 1; MTHFR, methylenetetrahydrofolate reductase; MMP, matrix metalloproteinase; TGF-β, transforming growth factor beta; BMPR, bone morphogenetic protein receptor; IL, interleukin; TNF-α, tumor necrosis factor alpha; MCP-1, monocyte chemoattractant protein 1; CCR-1, chemokine receptor-1; IFN-γ, gamma interferon; HFE, hemochromatosis; CPSI, carbamyl-phosphate synthetase 1; CYP, cytochrome P450 oxidase; GST, glutathione S-transferase; GSH=reduced glutathione; NO=nitric oxide.
  2. aThese genes were not studied in the setting of HSCT.
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