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Stem cell transplantation for congenital immunodeficiencies using reduced-intensity conditioning

Bone Marrow Transplantation volume 35, pages S45–S47 (2005)Cite this article

Summary:

The optimal preparation for stem cell transplantation (SCT) in children with congenital immunodeficiencies is currently unknown. In all, 81 children with immunodeficiency underwent 82 SCTs using reduced-intensity conditioning (RIC). The incidence of significant GVHD was low; viral reactivation was prominent with an unexpected increase in EBV reactivation; immune reconstitution was similar between different donor groups and comparable to conventional SCT. Overall, 68/81 (84%) survive with no significant difference between donor types or between severe combined immunodeficiency (SCID) and non-SCID diseases. Findings suggest a significant survival advantage in the unrelated donor setting for RIC compared to conventional SCT.

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References

  1. Rao K, Amrolia P, Jones A et al. Improved survival after unrelated donor bone marrow transplant in children with primary immunodeficiency using a reduced-intensity conditioning regimen. Blood 2005; 105: 879–885.

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Authors and Affiliations

  1. Great Ormond Street Hospital (GOSH) for Children NHS Trust, London, UK

    P Veys, K Rao & P Amrolia

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  1. P Veys
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  2. K Rao
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  3. P Amrolia
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Correspondence to P Veys.

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Veys, P., Rao, K. & Amrolia, P. Stem cell transplantation for congenital immunodeficiencies using reduced-intensity conditioning. Bone Marrow Transplant 35 (Suppl 1), S45–S47 (2005). https://doi.org/10.1038/sj.bmt.1704846

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  • DOI: https://doi.org/10.1038/sj.bmt.1704846

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