Abstract
REIS1–4 has demonstrated the presence of a phosphatase in various tissues specifically hydrolysing 5-nucleotides, for example, adenosine-5-phosphate. One of us has previously reported5 that normal blood serum has a low 5-nucleotidase activity corresponding to about 1/10 of its non-specific alkaline phosphatase activity towards glycerophosphate. In bone diseases where serum alkaline phosphatase is raised, serum 5-nucleotidase may be normal; but in jaundice, either infective or obstructive, both enzyme levels may be increased, those of the 5-nucleotidase sometimes exceeding those of the non-specific alkaline phosphatase.
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References
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Reis, J., Biochem. J., 46, xxi (1950).
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Dixon, T. F., Biochem. J., 50, xxxii (1952).
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DIXON, T., PURDOM, M. Serum 5-Nucleotidase. Nature 170, 500–501 (1952). https://doi.org/10.1038/170500a0
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DOI: https://doi.org/10.1038/170500a0
