Table 1 Echinocandins: some comparative data
Caspofungin | Micafungin | Anidulafungin | |
|---|---|---|---|
(A) Indications | esophageal candidiasis (EC), systemic candidiasis, febrile neutropenia (empiric therapy), invasive aspergillosis (salvage therapy) | esophageal candidiasis (EC), prophylaxis of candidiasis (pre-engraftment in stem cell transplant) | esophageal candidiasis (EC), systemic candidiasis (SC) |
(B) Dose | |||
Initial | 70 mg | No loading dose | 100 mg/day (EC) 200 mg/day (SC) |
Maintenance | 50 mg/day | 150 mg/day (EC) 50 mg/day (for prophylaxis) | 50 mg/day (EC) 100 mg/day (SC) |
(C) Higher doses found safe (package insert) | 100 mg/day × 21 days (15 subjects) 70 mg/day (limited data) | 8 mg/kg/day (up to 900 mg/day) | 260 mg followed by 130 mg/day |
