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Allografting

Outpatient allografting using non-myeloablative conditioning: the Mexican experience

Bone Marrow Transplantation volume 40, pages 119–123 (2007)Cite this article

Abstract

A group of 132 patients with both malignant and nonmalignant conditions was allografted using the ‘Mexican’ method of non-ablative conditioning. The conditioning was delivered on an outpatient basis and the procedure was planned to be conducted on outpatients in all cases. While 103 patients (78%) were able to complete the procedure totally as outpatients, 29 (22%) were hospitalized because of fever, mucositis or acute graft-versus-host disease. In a multivariate analysis, although differences were not statistically significant, it was found that the patients who were allografted as outpatients had higher levels of hemoglobin (12 versus 11.8 g/dl), higher platelet counts (248 versus 191 × 109/l), lower white blood cell counts (11.7 versus 12.4 × 109/l), higher Karnofsky scale scores (100 versus 90%) and lower creatinine levels (0.9 versus 0.93 mg/dl). A total of 86% of the patients with normal values for these variables could be allografted as outpatients, whereas only 67% of those with abnormal values completed the entire procedure as outpatients. It is concluded that allografting can be accomplished totally on an outpatient basis using the ‘Mexican’ reduced intensity-conditioning regimen.

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Authors and Affiliations

  1. Servicio de Hematología, Hospital Universitario ‘Dr José Eleuterio González', Universidad Autónoma de Nuevo León, Nuevo León, México

    O G Cantú-Rodríguez, J C Jaime-Pérez, C H Gutiérrez-Aguirre, O González-Llano, C Mancías-Guerra, L C Tarín-Arzaga, G J Ruiz-Delgado, C C Sandoval-Villa, J Marfil-Rivera & D Gómez-Almaguer

  2. Centro de Hematología y Medicina Interna de Puebla, Puebla, México

    A Morales-Toquero & G J Ruiz-Argüelles

Authors
  1. O G Cantú-Rodríguez
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  2. J C Jaime-Pérez
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  3. C H Gutiérrez-Aguirre
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  4. O González-Llano
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  5. C Mancías-Guerra
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  6. L C Tarín-Arzaga
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  7. G J Ruiz-Delgado
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  8. C C Sandoval-Villa
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  9. J Marfil-Rivera
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  10. A Morales-Toquero
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  11. G J Ruiz-Argüelles
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  12. D Gómez-Almaguer
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Correspondence to D Gómez-Almaguer.

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Cantú-Rodríguez, O., Jaime-Pérez, J., Gutiérrez-Aguirre, C. et al. Outpatient allografting using non-myeloablative conditioning: the Mexican experience. Bone Marrow Transplant 40, 119–123 (2007). https://doi.org/10.1038/sj.bmt.1705700

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  • DOI: https://doi.org/10.1038/sj.bmt.1705700

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