Abstract
MANY methods have already been described for the selective degradation of peptides from the carboxyl end1. However, the several chemical steps involved in those procedures do not allow their utilization on a micro-scale. Linstead, Shephard and Weedon2 have recently published a study on the decarboxylation of α-N-acylamino-acids in alcoholic media by anodic oxidation into alkoxyalkylamides (acylaminoethers), with a 74–91 per cent yield.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bergmann, M., and Zervas, L., J. Biol. Chem., 113, 341 (1936). Bettzieche, F., and Menger, R., Z. physiol. Chem., 161, 37 (1926). Chibnall, A. C., and Rees, M., Biochem. J., 48, xlvii (1951). Fromageot, C., et al., Biochim. Biophys. Acta, 6, 283 (1950). Schlack, P., and Kumpf, W., Z. physiol. Chem., 154, 125 (1926). Tibbs, J., Nature, 168, 910 (1951). Khorana, H. G., J. Chem. Soc., 2081 (1952). Watson, S. G., and Waley, J., J. Chem. Soc., 2394 (1951).
Linstead, R. P., Shephard, B. R., and Weedon, B. C. L., J. Chem. Soc., 2854 (1951).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BOISSONNAS, R. Stepwise Degradation of Polypeptides from the Carboxyl End. Nature 171, 304 (1953). https://doi.org/10.1038/171304a0
Issue date:
DOI: https://doi.org/10.1038/171304a0
