Abstract
ELECTRON micrographs of normal connective tissue reveal a very fine protein network superimposed on a much coarser network1. The interstices are filled with protofibrils and mucopolysaccharidic acids of high molecular weight. Fibrous connective tissue is produced when lung tissue is degenerated by silica particles, the silicic acid formed by the dissolution of the silica probably being involved, and the possible analogy between the role of silicic acid and that of the mucopolysaccharides is evident.
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HOLT, P., OSBORNE, S. Formation of Silicotic Tissue. Nature 171, 892 (1953). https://doi.org/10.1038/171892a0
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DOI: https://doi.org/10.1038/171892a0
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