Abstract
THE pattern of the metabolic response of man to injury (for example, fracture of a long bone), in particular its effect on protein catabolism, has been under investigation for some time by one of us1 as this phenomenon is of basic importance to our understanding of protein metabolism in general. The reaction is characterized in man by a marked increase in the urinary excretion of nitrogen and sulphur, which reaches a peak from the fourth to the eighth day after the injury and then slowly declines. There is also a loss of phosphorus and potassium. This phenomenon has been confirmed by many workers and in other forms of injury2. Cuthbertson, McGirr and Robertson3 have also found the same thing to occur in the rat, though rather earlier. The losses appear to be more general than local in origin.
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CAMPBELL, R., SHARP, G., BOYNE, A. et al. Cortisone and the Metabolic Response to Injury. Nature 172, 158–160 (1953). https://doi.org/10.1038/172158b0
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DOI: https://doi.org/10.1038/172158b0
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