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Tryptophane Metabolites in Human Urine

Nature volume 172, page 204 (1953)Cite this article

Abstract

I HAVE already reported1 that some human urine specimens made strongly alkaline yield distillates presenting spectroscopic and polarographic properties of o-aminoacetophenone. This was interpreted as indicating the presence of kynurenine in human urine, since (1) o-aminoacetophenone is not present in untreated urine, and (2) no substance other than kynurenine was known to behave in the way described under the condition of experiment. Tabone's interpretation2, that the source of o-aminoacetophenone in human urine is tryptophane, was based on rather different and qualitative experiments.

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References

  1. Špaček, M., C.R. Soc. Biol., 141, 1074 (1947).

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  2. Tabone, J., Bull. Soc. Chim. Biol., 31, 701 (1949).

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  3. Hawk, P. B., and Bergheim, O., “Practical Physiological Chemistry”. 2nd ed., 126.

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Authors and Affiliations

  1. Division of Laboratories, Dept. of Health and Welfare, Charlottetown, Prince Edward Island

    M. ŠPAČEK

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  1. M. ŠPAČEK
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ŠPAČEK, M. Tryptophane Metabolites in Human Urine. Nature 172, 204 (1953). https://doi.org/10.1038/172204a0

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