Abstract
ATTEMPTS to establish the mechanism and site of action of thyroxine upon peripheral tissues have occupied the interest of a number of investigators, and a detailed account of the various areas of study has been presented in Barker's1 review. Of the various possibilities suggested, it may be mentioned that thyroxine has been stated to cause a release of co-enzymes, protein carriers or other substances needed for many of the energy-transforming processes in cells2,3; but neither the mechanism of release nor the source of these materials is clear. Martius and Hess4 have suggested that thyroxine acts as an uncoupling agent.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Barker, S. B., Physiol. Rev., 31, 205 (1951).
Drabkin, D. L., J. Biol. Chem., 182, 335, 351 (1950).
Tipton, S. R., Amer. J. Physiol., 161, 29 (1950).
Martius, C., and Hess, B., Arch. Biochem., 33, 486 (1951).
Kaplan, N. O., and Lipmann, F., J. Biol. Chem., 174, 37 (1948).
Van Wessem, R., Tabachnick, I. I. A., and Bonnycastle, D. D. (unpublished data, 1953).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TABACHNICK, I., BONNYCASTLE, D. Effect of Thyroxine on Coenzyme A Levels. Nature 172, 400 (1953). https://doi.org/10.1038/172400a0
Issue date:
DOI: https://doi.org/10.1038/172400a0
This article is cited by
-
Das coenzym a und seine biologischen funktionen
Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie (1957)
