Abstract
Katchalski, Berger and Neumann1 have recently described the inhibition of pepsin by polylysine, polyornithine and poly-p-amino-phenylalanine. We would suggest that this is not an isolated effect but is an example of a widespread non-specific action of high molecular weight polyelectrolytes on many enzymes.
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References
Katchalski, E., Berger, A., and Neumann, H., Nature, 173, 998 (1954).
Hahn, L., Nature, 170, 282 (1952). Hahn, L., and Fekete, J., Acta Chem. Scand., 7, 798 (1953). Hahn, L., and Frank, E., Acta Chem. Scand., 7, 806 (1953).
Diezfalusy, E., Fernö, O., Fex, H., Högberg, B., Linderot, T., and Rosenberg, Th., Acta Chem. Scand., 7, 913 (1953). Fernö, O., Fex, H., Högberg, B., Linderot, T., and Rosenberg, Th., Acta Chem. Scand., 7, 921 (1953).
Rogers, H. J., Biochem. J., 40, 583 (1946).
Zöllner, N., and Felling, J., Naturwiss., 39, 523 (1952). Roth, J. S., Arch. Biochem. and Biophys., 44, 265 (1953).
Myrbäck, K., and Persson, B., Arkiv. Chem., 5, 177 (1952).
Hadidian, Z., and Pirie, N. W., Biochem. J., 42, 266 (1948).
Astrup, T., and Alkjaersig, N., Nature, 166, 568 (1950).
Rogers, H. J., and Spensley, P. C., Biochim. et Biophys. Acta, 13, 293 (1954).
Pantlitschko, M., and Kaiser, E., Biochem. Z., 322, 137 (1951).
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SPENSLEY, P., ROGERS, H. Enzyme Inhibition. Nature 173, 1190 (1954). https://doi.org/10.1038/1731190a0
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DOI: https://doi.org/10.1038/1731190a0
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