Abstract
WE have tried to overcome the well-known difficulty of preparing aqueous solutions of steroids by the use of detergents. We have been interested further in the study of the behaviour of the detergents themselves and of steroid-detergent mixtures in the electric field and in the practicability of separating steroids by this means. One of us1 has described the application of paper electrophoresis for separating steroids after esterifying with anhydrous succinic acid and forming the sodium salt. There are very full accounts of protein-detergent complexes and their behaviour in the electric field2,3. Polonovski4 has recorded his studies of the dissolving power of invert soaps in cholesterol, lecithin, cerobrosides and glycerides; but we were unable to find any similar observations on steroids and detergents.
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References
Voigt, K. D., and Beckmann, I., Acta Endocrin., 13, 19 (1953); 15, 251 (1954).
Jerchel, D., and Scheurer, H., Z. Naturforsch., 8 b, 541 (1953).
Putnam, F. W., “Adv. Protein Chemistry”, 6, 79 (1948).
Polonovski, J., Ann. Chim., 5, 671 (1950).
v. Holt, C., Voigt, K. D., and Gaede, K., Biochem. Z., 323, 345 (1952).
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SCHMID, O., VOIGT, K. Solubility and Electrophoretic Behaviour of Steroid-Detergent Mixtures in Aqueous Buffers. Nature 174, 129–130 (1954). https://doi.org/10.1038/174129b0
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DOI: https://doi.org/10.1038/174129b0
