Abstract
BURCHENAL and his colleagues have reported that 4-amino-10-methylpteroylglutamic acid (amethopterin) prolongs the lives of mice implanted experimentally with leukæmia1, and that folinic acid antagonizes this therapeutic effect more potently than does pteroylglutamic acid2. Accepting the view that the antifolinic acid activity of amethopterin is related to its therapeutic effect in leukæmia, we have explored for such activity a number of 2 : 4-diamino-pteridines3,4,5 already known to be antagonists of pteroylglutamic acid6, with the view of their possible clinical use.
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COLLIER, H., PHILLIPS, M. Some 2 : 4-Diaminopteridines as Folinic Acid Antagonists. Nature 174, 180–181 (1954). https://doi.org/10.1038/174180a0
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DOI: https://doi.org/10.1038/174180a0
