Abstract
NEONATAL rats have been treated with cortisone acetate (Merck ; Roussel) in doses of 0.25–5 mgm./day subcutaneously, control litter mates being given the same dosage of suspending medium. The experiments were undertaken primarily to test the effect upon microglial immigration and transformation in the brain. Hortega's neonatal ‘fountains’ were found to be completely suppressed within 24–36 hr. of a single dose of 2.5 mgm. of cortisone, and in older animals myelination was retarded.
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FIELD, E. Effect of Cortisone on the Neonatal Rat. Nature 174, 182 (1954). https://doi.org/10.1038/174182a0
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DOI: https://doi.org/10.1038/174182a0
