Abstract
A RECENT publication1 prompts us to report the preparation of a number of novel synthetic antispasmodics related to papaverine. The numerous synthetic analogues of papaverine (I) which have been prepared (see, for example, Blicke2) can be divided into two main groups : (1) those with an intact isoquinoline ring system (for example, eupaverine3) and (2) those in which the isoquinoline ring has been opened at the line a—a to give a bis-(2-phenylethyl)amine (for example, sestron4). 
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References
Heinzelman and Aspergren, J. Amer. Chem. Soc., 75, 3409 (1953).
Blicke, Ann. Rev. Biochem., 13, 549 (1944).
Kreitmair, Arch. Exp. Pathol. Pharmakol., 164, 509 (1932).
Külz and Rosenmund, Klin. Wochschr., 17, 345 (1938).
Mercier, Lespagnol and Mercier, C.R. Soc. Biol., 143, 1123 (1949).
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CYMERMAN-CRAIG, J., MARTIN, K., WAILES, P. et al. New Synthetic Antispasmodics. Nature 174, 231 (1954). https://doi.org/10.1038/174231a0
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DOI: https://doi.org/10.1038/174231a0
