Abstract
EXPERIMENTS with early amphibian embryos, using glycine-1-14C as a tracer and the autoradiographic technique of Doniach and Pelc1, have shown that the nuclei take up this substance into high-molecular weight compounds more rapidly than does the cytoplasm2. Ficq3 has also observed a greater activity in the nuclei, using orotic acid-2-14C as well as glycine-1-14C. She points out that, by the neural-tube stage, incorporation has occurred in all tissues which are actively engaged in morphogenesis; and she has shown that the labelled substances were taken up into nucleic acids as well as protein.
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References
Doniach, I., and Pelc, S. R., Brit. J. Radiol., 23, 184 (1950).
Waddington, C. H., and Sirlin, J. L. (in the press). cf. Nature, 173, 517 (1954).
Ficq, A., Experientia, 10, 20 (1954).
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SIRLIN, J., WADDINGTON, C. Nuclear Uptake of Glycine-2-14C in the Newt Embryo. Nature 174, 309 (1954). https://doi.org/10.1038/174309a0
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DOI: https://doi.org/10.1038/174309a0
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