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Intracellular Sites of Metabolism of 3 : 4 Benzpyrene in Mouse Liver

Nature volume 174, page 841 (1954)Cite this article

Abstract

PREVIOUS work1 has shown that after intravenous injection of colloidal 3 : 4 benzpyrene the bulk of the carcinogen is held in the liver. Excretion takes place over approximately twenty-four hours, the hydrocarbon having undergone metabolic oxidation to one or other of two compounds labelled BpX 1 or BpX 2. These are oxidation products and have been characterized by physical methods and analogy with known derivatives of other polycyclic hydrocarbons as being: 8(OR 1) − 9(OH) − 8,9 dihydro 3 : 4 benzpyrene and 8(OR 1) − 9(OR 2) − 8,9 dihydro benzpyrene respectively. The groups R 1 and R 2 are, at present, unidentified radicals. It has also been found1,2 that during metabolic oxidation the products derived from 3 : 4 benzpyrene are firmly bound within the tissues where they are formed.

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References

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Authors and Affiliations

  1. Department of Cancer Research, Mount Vernon Hospital,

    G. CALCUTT & S. PAYNE

  2. the Radium Institute, Northwood, Middlesex

    G. CALCUTT & S. PAYNE

Authors
  1. G. CALCUTT
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  2. S. PAYNE
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CALCUTT, G., PAYNE, S. Intracellular Sites of Metabolism of 3 : 4 Benzpyrene in Mouse Liver. Nature 174, 841 (1954). https://doi.org/10.1038/174841a0

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