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Intracellular Distribution of Xanthine Oxidase in the Rat Liver

Nature volume 175, page 1087 (1955)Cite this article

Abstract

THE separation of cytoplasmic particles into fractions by differential centrifugation has been extensively used for the study of the distribution of intracellular cell constituents. Some enzymes of oxidative metabolism have been shown to be localized chiefly in the fraction of the liver containing large particles (mitochondria)1. During the course of an investigation of the xanthine oxidase of the rat liver, we have studied the intracellular distribution of this enzyme, since there seem to be no data in tho literature.

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Authors and Affiliations

  1. Biochemical Laboratory, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil

    GILBERTO G. VILLELA, EMILIO MITIDIERI & OTTÍLIA R. AFFONSO

Authors
  1. GILBERTO G. VILLELA
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  2. EMILIO MITIDIERI
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  3. OTTÍLIA R. AFFONSO
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VILLELA, G., MITIDIERI, E. & AFFONSO, O. Intracellular Distribution of Xanthine Oxidase in the Rat Liver. Nature 175, 1087 (1955). https://doi.org/10.1038/1751087a0

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