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Cephalosporin C, a New Antibiotic containing Sulphur and D-α-Aminoadipic Acid

Nature volume 175, page 548 (1955)Cite this article

Abstract

A SPECIES of Cephalosporium produces a hydrophilic penicillin, called cephalosporin N, which yields D-α-aminoadipie acid on hydrolysis1. Crude preparations of cephalosporin N have been found to show strong absorption in ultra-violet light at 260 mμ, although highly purified cephalosporin N shows very little absorption at this wave-length. A new antibiotic with an absorption maximum at 260 mμ has now been isolated from the crude preparations in the form of a crystalline sodium salt. It resembles cephalosporin N in certain physical, chemical and biological properties, but differs from it sharply in others.

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References

  1. Newton, G. G. F., and Abraham, E. P., Nature, 172, 395 (1953); Biochem. J., 58, 103 (1954).

    Article  ADS  CAS  Google Scholar 

  2. Thompson, H. W., Brattain, R. R., Randall, H. M., and Rasmussen, R. S., “The Chemistry of Penicillin”, chapter 13 (Princeton University Press, 1949).

    Google Scholar 

  3. Manson, E. E. D., Pollock, M. R., and Tridgell, E. J., J. Gen. Microbiol., 11, 493 (1954).

    Article  CAS  Google Scholar 

  4. Pollock, M. R., and Torriani, Anne-Marie, C.R. Acad. Sci., Paris, 237, 276 (1953).

    CAS  Google Scholar 

  5. Abraham, E. P., Newton, G. G. F., and Hale, C. W., Biochem. J., 58, 94 (1954).

    Article  CAS  Google Scholar 

  6. Gottshall, R. Y., Roberts, J. M., Portwood, L. M., and Jennings, J. C., Proc. Soc. Exp. Biol. Med., 76, 307 (1951).

    Article  CAS  Google Scholar 

  7. Abraham, E. P., Newton, G. G. F., Crawford, K., Burton, H. S., and Hale, C. W., Nature, 171, 343 (1953).

    Article  ADS  CAS  Google Scholar 

  8. Olson, B. H., Jennings, J. C., and Junek, A. J., Science, 117, 76 (1953). Olson, B. H., Jennings, J. C., Pisano, M., and Junek, A. J., Antibiotics and Chemotherapy, 4, 1 (1954).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Sir William Dunn School of Pathology, University of Oxford,

    G. G. F. NEWTON & E. P. ABRAHAM

Authors
  1. G. G. F. NEWTON
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  2. E. P. ABRAHAM
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NEWTON, G., ABRAHAM, E. Cephalosporin C, a New Antibiotic containing Sulphur and D-α-Aminoadipic Acid. Nature 175, 548 (1955). https://doi.org/10.1038/175548a0

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