Pseudocholinesterase in Pacinian Corpuscles

Abstract

WE have recently studied the distribution of cholinesterases in the cat's pancreas by Koelle's histochemical method¹, and observed that among other structures which contain enzyme the Pacinian corpuscles are prominent. The cholinesterase was seen to be concentrated in the core and stalk of this sensory organ (Fig. 1). By the use of appropriate substrates (acetyl- and butyryl-thiocholine) and a selective inhibitor (diisopropyl-fluoro-phosphate) the enzyme has been identified as pseudocholinesterase. Although the Pacinian corpuscles found in this situation are not pancreatic structures, being part of the enfolding mesentery, their location here is convenient because it is easier to section them when supported by the glandular tissue than when they are lying free in the mesentery.