Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Mode of Action of isoNicotinic Hydrazide

Abstract

THE high specific activity of isonicotinic hydrazide (isoniazid; I) against Myco. tuberculosis suggests interference with an essential metabolite.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Albert, Experientia, 9, 370 (1953).

    Article  Google Scholar 

  2. Sorkin, Roth, and Erlenmeyer, Helv. Chim. Acta, 35, 1736 (1952).

    Article  CAS  Google Scholar 

  3. Fallab and Erlenmeyer, Experientia, 8, 298 (1952).

    Article  CAS  Google Scholar 

  4. Coleman, Amer. Rev. Tuberc., 69, 1062 (1954).

    CAS  Google Scholar 

  5. Bernstein, Jambor, Lott, Pansy, Steinberg and Yale, Amer. Rev. Tuberc., 67, 354 (1953).

    CAS  Google Scholar 

  6. Cymerman-Craig, Rubbo and Pierson, Brit. J. Exp. Path., 35, 478 (1954).

    CAS  Google Scholar 

  7. Pope, Amer. Rev. Tuberc., 68, 938 (1953).

    CAS  Google Scholar 

  8. Baddiley, Nature, 170, 711 (1952).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

CYMERMAN-CRAIG, J., WILLIS, D., RUBBO, S. et al. Mode of Action of isoNicotinic Hydrazide. Nature 176, 34–35 (1955). https://doi.org/10.1038/176034a0

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/176034a0

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing