Abstract
Two distinct reduction products of vitamin B12 have been described in the literature, by Diehl and Murie1 and by Boos, Carr and Conn2; we shall refer to these as I and II respectively. They differ in their method of preparation, and have widely different absorption spectra in the visible and ultra-violet, but may both be re-oxidized to vitamin B12a by exposure to air, and from polarographic and titrimetric evidence both are claimed to contain divalent cobalt.
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References
Diehl, H., and Murie, R., Iowa State Coll. J. Sci., 26, 555 (1952). Cf. Jaselskis, B., and Diehl, H., J. Amer. Chem. Soc., 76, 4345 (1954).
Boos, R. N., Carr, J. E., and Conn, J. B., Science, 117, 603 (1953). See also Schindler, O., Helv. Chim. Acta, 34, 1356 (1951).
Brockman, jun., J. A., Pierce, J. V., Stokstad, E. L. R., Brognist, H. P., and Jukes, T. H., J. Amer. Chem. Soc., 72, 1042 (1950).
Beaven, G. H., Holiday, E. R., Johnson, E. A., Ellis, B., and Petrow, V., J. Pharm. Pharmacol., 2, 733, 944 (1950). Davies, M. T., Mamalis, P., Petrow, V., Sturgeon, B., Beaven, G. H., Holiday, E. R., and Johnson, E. A., ibid., 4, 448 (1952).
Hodgkin, D. C., Pickworth, J., Robertson, J. H., Trueblood, K. N., Prosen, R. J., and White, J. G., Nature, 176, 325 (1955).
Bennett, R., Cannon, J. R., Johnson, A. W., Sutherland, I., Todd, A. R., and Lester Smith, E., Nature, 176, 328 (1955).
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BEAVEN, G., JOHNSON, E. The Reduction of Vitamin B12. Nature 176, 1264–1265 (1955). https://doi.org/10.1038/1761264b0
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DOI: https://doi.org/10.1038/1761264b0
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