Abstract
IT has been reported from this laboratory1 that, although acetoacetate alone causes an increase in the susceptibility to alloxan diabetes in rabbits, the product prepared by condensing acetoacetate with glucose (namely, 2-tetrahydroxy butyl, 5-methyl, 4-carboxy furan), in the form of its sodium salt, when injected intraperitoneally or intravenously in rats and rabbits in the proportion of 1.5:1 with alloxan or even less, can prevent alloxan diabetes2. It has also recently been shown by Nath and Bhattathiry (unpublished results) that 1:2 dienol glucose, which is liberated from this condensation product on hydrolysis, reacts with alloxan.
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References
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NATH, M., BHATTATHIRY, E. Reaction of Alloxan with Ascorbic Acid. Nature 176, 787–788 (1955). https://doi.org/10.1038/176787a0
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DOI: https://doi.org/10.1038/176787a0
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