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Reaction of Alloxan with Ascorbic Acid

Abstract

IT has been reported from this laboratory1 that, although acetoacetate alone causes an increase in the susceptibility to alloxan diabetes in rabbits, the product prepared by condensing acetoacetate with glucose (namely, 2-tetrahydroxy butyl, 5-methyl, 4-carboxy furan), in the form of its sodium salt, when injected intraperitoneally or intravenously in rats and rabbits in the proportion of 1.5:1 with alloxan or even less, can prevent alloxan diabetes2. It has also recently been shown by Nath and Bhattathiry (unpublished results) that 1:2 dienol glucose, which is liberated from this condensation product on hydrolysis, reacts with alloxan.

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References

  1. Nath, M. C., Gadgil, J. S., and Hatwalne, V. G., Biochem. J., 53, 481 (1953).

    Article  CAS  Google Scholar 

  2. Nath, M. C., and Sahu, V. K., Science, 119, 349 (1954), and other work. Nath, M. C., and Bhattathiry, E. P. M. (in the press).

    Article  ADS  CAS  Google Scholar 

  3. West, E. S., and Rinehart, R. E., J. Biol. Chem., 146, 105 (1942).

    CAS  Google Scholar 

  4. Bessey, O. A., J. Assoc. Official Agric. Chem., 27, 537 (1944).

    CAS  Google Scholar 

  5. Roe, J. M., and Keuther, C. A., J. Biol. Chem., 147, 399 (1943).

    CAS  Google Scholar 

  6. Bailey, C. C., Bailey, O. T., and Leech, R. S., Bull. New England Med. Center, 7, 59 (1945).

    Google Scholar 

  7. Brükmann, G., and Wertheimer, E., J. Biol. Chem., 168, 241 (1947).

    Google Scholar 

  8. Levey, S., and Suter, B., Proc. Soc. Exp. Biol. and Med., 63, 341 (1946).

    Article  CAS  Google Scholar 

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NATH, M., BHATTATHIRY, E. Reaction of Alloxan with Ascorbic Acid. Nature 176, 787–788 (1955). https://doi.org/10.1038/176787a0

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