Abstract
THE high in vitro activity of 1-iso nicotinoyl-2-veratrylidene hydrazine (0.06 µgm. per ml.), henceforth referred to as verazide, has been previously reported by us1 and others2,3. Fox and Gibas4 report that 2 : 2-alkylidene derivatives of isoniazid (among which was included verazide) were markedly tuber-culostatic in mouse tuberculosis. There is no refer-ence, however, to the degree of activity of verazide or to its activity when given by intermittent dosage.
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References
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Shchukina, Pershin, Makeeva, Sazonova, Nikitskaya, Yanina and Yakovleva, Doklady Akad. Nauk. U.S.S.R., 84, 981 (1952).
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Elmendorf, Cawthon, Muschenheim and McDermott, Amer. Rev. Tuberc., 65, 429 (1952).
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RUBBO, S., CYMERMAN-CRAIG, J. Anti-Tuberculous Activity of Verazide (1-isoNicotinoyl-2-veratrylidene Hydrazine). Nature 176, 887 (1955). https://doi.org/10.1038/176887a0
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DOI: https://doi.org/10.1038/176887a0
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