Abstract
IN two separate experiments it has been found that, 24 hr. after the administration of bovine pituitary growth hormone to mice with the hereditary syndrome of obesity and hyperglycæmia (1 mgm. of growth hormone per mouse), changes had occurred in the amounts of insulin and hyperglycæmic-glycogenolytic factor extractable from the pancreas using a standardized acid alcohol technique1. In each experiment values for insulin and hyperglycæmic-glycogenolytic factor values were compared in the following four groups of animals (ten or twelve animals per group) : obese-hyperglycæmic mice and their non-obese sibs treated with growth hormone, and two groups of the same description but not treated with growth hormone.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Scott, D., and Fisher, A. M., Amer. J. Physiol., 121, 253 (1938).
Anderson, E., and Long, J. A., Endocrin., 40, 92 (1947).
Foa, P. P., Santamaria, L., Weinstein, H. R., Berger, S., and Smith, J. A., Amer. J. Physiol., 171, 32 (1952).
Brown, E. M., Dohan, F. C., Freedman, L. R., DeMoor, P., and Lukens, F. D. W., Endocrin., 50, 644 (1952).
Wrenshall, G. A., Andrus, S. B., and Mayer, J., Endocrin., 56, 335 (1955).
Shull, K. H., and Mayer, J., J. Biol. Chem., 218, 885 (1956).
Sutherland, E. W., Ann. New York Acad. Sci., 54, 693 (1951).
Mayer, J., Andrus, S. B., and Silides, D. J., Endocrin., 53, 572 (1953).
Mayer, J., and Silides, D. J., Endocrin., 52, 54 (1953).
Bornstein, J., Reid, E., and Young, F. G., Nature, 168, 903 (1951).
Shull, K. H., and Mayer, J., Endocrin. (in the press). Sirek, O., Sirek, A., and Best, C. H., Proc. Canad. Physiol. Soc., 19th annual meeting, 57 (October 1955).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CLARKE, D., WRENSHALL, G. & MAYER, J. Effects of Pituitary Growth Hormone on the Insulin and Hyperglycæmic-glycogenolytic Factor extractable from the Pancreas of Obese-Hyperglycæmic Mice. Nature 177, 1235 (1956). https://doi.org/10.1038/1771235a0
Issue date:
DOI: https://doi.org/10.1038/1771235a0
This article is cited by
-
The relationship between the hyperplastic pancreatic islet and insulin insensitivity in obesity
Acta Diabetologica Latina (1981)
-
Studies of hereditary-obese mice (obob) after implantation of pancreatic islets in Millipore filter capsules
Diabetologia (1970)
-
The effect of glucagon on pressure and oxygen saturation of splanchnic venous blood
The American Journal of Digestive Diseases (1966)
