Abstract
IN our earlier report we directed attention to the importance of chelation as an essential step in the anti-tuberculous activity of isonicotinic hydrazide (isoniazid)1. It was impossible to decide whether the chelating action with a metal or metals took place before (in the medium) or after adsorption on the bacterial cell.
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References
Cymerman-Craig, Rubbo, Willis and Edgar, Nature, 176, 34 (1955).
Rubbo, Albert and Gibson, Brit. J. Exp. Path., 31, 425 (1950).
Rubbo and Pierson, Amer. Rev. Tuberc., 68, 48 (1953).
Rubbo and Cymerman-Craig, Nature, 176, 887 (1955).
Cymerman-Craig, Rubbo and Pierson, Brit. J. Exp. Path., 35, 478 (1954).
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RUBBO, S., EDGAR, J., CYMERMAN-CRAIG, J. et al. Mode of Action of Isonicotinic Hydrazide. Nature 177, 480 (1956). https://doi.org/10.1038/177480a0
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DOI: https://doi.org/10.1038/177480a0
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