Abstract
A RECENT reference in the literature1 suggests that there may be no pseudo-cholinesterase in the central nervous system of the frog. The conclusion is based on two kinds of evidence: (1) with Warburg manometric technique the tissue did not split significant quantities of benzoylcholine; and (2) there was evidently no splitting of butyrylthiocholine when the tissue was examined histochemically by Koelle's2 modified technique. Our own evidence suggests that this conclusion is incorrect.
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Shen, S. C., Greenfield, P., and Boell, E. J., J. Comp. Neurol., 102, 717 (1955).
Koelle, G., J. Pharmacol., 103, 153 (1951).
Myers, D. K., Biochem. J., 55, 67 (1953). Mendel, B., and Myers, D. K., Nature, 176, 783 (1955).
Hebb, C. O., Pharmacol. Rev., 6, 39 (1954).
Koelle, G., J. Pharmacol., 100, 158 (1950).
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HARDWICK, D., HEBB, C. Pseudo-Cholinesterase in the Central Nervous System of the Frog. Nature 177, 667 (1956). https://doi.org/10.1038/177667a0
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DOI: https://doi.org/10.1038/177667a0
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