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Amino-acid Sequence of a Melanophore-stimulating Peptide

Abstract

A HIGHLY active melanophore-stimulating polypeptide has been isolated from hog posterior pituitary extracts1. The amino-acid composition2 of the active substance (MSH) is consistent with the view that it is an octadecapeptide containing the following amino-acid residues: Arg1 Asp2, Glu2, Gly2, His1, Lys2, Met1 Phe1 Pro3, Ser1 Try1, Tyr1

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References

  1. Porath, J., Roos, P., Landgrebe, F. W., and Mitchell, G. M., Biochim. Biophys. Acta., 17, 598 (1955).

    Article  CAS  Google Scholar 

  2. Roos, P., Acta Chem. Scand. (in the press).

  3. Fraenkel-Conrat, H., J. Amer. Chem. Soc., 76, 3606 (1954).

    Article  CAS  Google Scholar 

  4. Harris, J. I., and Li, C. H., J. Amer. Chem. Soc., 76, 3607 (1954).

    Article  CAS  Google Scholar 

  5. Harris, J. I., “Symposium on Peptide Chemistry”, Chem. Soc. Spec. Pub., 2, 71 (1955).

    Google Scholar 

  6. Léonis, J., private communication.

  7. Sanger, F., and Tuppy, H., Biochem. J., 49, 463 (1951).

    Article  CAS  Google Scholar 

  8. Bell, P. H., J. Amer. Chem. Soc., 76, 5565 (1954).

    Article  CAS  Google Scholar 

  9. Li, C. H., Geschwind, I. I., Cole, R. D., Raacke, I. D., Harris, J. I., and Dixon, J. S., Nature, 176, 687 (1955).

    Article  ADS  CAS  Google Scholar 

  10. Dixon, H. B. F., Biochim. Biophys. Acta, 19, 392 (1956).

    Article  CAS  Google Scholar 

  11. du Vigneaud, V., “The Harvey Lectures”, New York, Series L, 1 (1954).

    Google Scholar 

Download references

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HARRIS, J., ROOS, P. Amino-acid Sequence of a Melanophore-stimulating Peptide. Nature 178, 90 (1956). https://doi.org/10.1038/178090a0

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